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Article

Genomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control.

Genetics - 1 Jul 2009

Copic Alenka, Dorrington Mariana, Pagant Silvere, Barry Justine, Lee Marcus C S, Singh Indira, Hartman John L, Miller Elizabeth A

Abstract excerpt

To gain new mechanistic insight into ER homeostasis and the biogenesis of secretory proteins, we screened a genomewide collection of yeast mutants for defective intracellular retention of the ER chaperone, Kar2p. We identified 87 Kar2p-secreting strains, including a number of known components in secretory protein modification and sorting. Further characterization of the 73 nonessential Kar2p retention mutants...

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Identifiers

PMID: 19433630
DOI: 10.1534/genetics.109.101105
PMCID: PMC2710157

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GPI

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Source receipt: pubmed, retrieved 7 Sept 2026.

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