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Article

Functional properties of a novel mutant of staphylokinase with platelet-targeted fibrinolysis and antiplatelet aggregation activities.

European journal of pharmacology - 2 Jul 2007

Chen Hongshan, Mo Wei, Zhang Yanling, Su Huabo, Ma Janying, Yao Ruiming, Zhang Shaoheng, Ge Junbo, Song Houyan

Abstract excerpt

The present study was performed to characterize the functional properties of RGD-SAK, a novel mutant of staphylokinase (SAK). Biochemical analysis indicated that RGD-SAK maintained the similar structure and the fibrinolytic function of SAK. Measurement of platelet binding activity in vitro demonstrated that RGD-SAK had a much higher affinity with platelets than SAK. In vitro platelet-rich clot lysis assay...

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Source

Identifiers

PMID: 17451675
DOI: 10.1016/j.ejphar.2007.03.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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