Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion.

doi:10.1083/jcb.135.6.1643

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Article

Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion.

The Journal of cell biology - 1 Dec 1996

Islam S, Carey T E, Wolf G T, Wheelock M J, Johnson K R

Abstract excerpt

E-cadherin is a transmembrane glycoprotein that mediates calcium-dependent, homotypic cell-cell adhesion and plays an important role in maintaining the normal phenotype of epithelial cells. Disruption of E-cadherin activity in epithelial cells correlates with formation of metastatic tumors. Decre...

Topics

Cadherins
Carcinoma, Squamous Cell
Cell Adhesion
Cell Differentiation
DNA, Antisense
Fibroblasts
Humans
Neoplasm Invasiveness
Phenotype
Transfection
Tumor Cells, Cultured

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