Article
The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism.
Endocrine reviews - 1 Aug 1996
Chattopadhyay N, Mithal A, Brown E M
Abstract excerpt
The recent cloning of a [Ca2+]o-sensing receptor from several different tissues in several species directly demonstrates that a variety of cells can directly recognize and respond to small changes in their ambient level of [Ca2+]o through a G protein-coupled, cell surface receptor. This finding directly documents that [Ca2+]o can act as an extracellular, first messenger in addition to subserving its better known...
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