Activating mutations of the Ca2+-sensing receptor.

doi:10.1006/mgme.1998.2716

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Article

Activating mutations of the Ca2+-sensing receptor.

Molecular genetics and metabolism - 1 Jul 1998

Mancilla E E, De Luca F, Baron J

Abstract excerpt

The Ca2+-sensing receptor (CaR) is a member of the seven-transmembrane domain, G-protein-coupled receptor superfamily. It is expressed in parathyroid, kidney, and other tissues. In parathyroid, activation of the CaR by extracellular Ca2+ negatively regulates the secretion of parathyroid hormone....

Topics

Calcium
Cell Line
Homeostasis
Humans
Hypoparathyroidism
Models, Molecular
Mutation
Parathyroid Glands
Receptors, Calcium-Sensing
Receptors, Cell Surface
Signal Transduction

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