Article
An elongation factor Tu (EF-Tu) resistant to the EF-Tu inhibitor GE2270 in the producing organism Planobispora rosea.
Molecular microbiology - 1 Oct 1996
Sosio M, Amati G, Cappellano C, Sarubbi E, Monti F, Donadio S
Abstract excerpt
Using a cell-free protein-synthesis system, we have established that the elongation factor (EF) Tu (EF-Tu) of the actinomycete Planobispora rosea, the producer of the thiazolyl peptide GE2270, a specific EF-Tu inhibitor, is highly resistant to its own antibiotic, while it is completely inhibited...
Topics
- ATP-Binding Cassette Transporters
- Actinomycetales
- Amino Acid Sequence
- Anti-Bacterial Agents
- Carrier Proteins
- Cloning, Molecular
- Conserved Sequence
- Dose-Response Relationship, Drug
- Drug Resistance, Microbial
- Escherichia coli
- Escherichia coli Proteins
- Genes, Bacterial
- Maltose-Binding Proteins
- Models, Molecular
- Molecular Sequence Data
- Monosaccharide Transport Proteins
- Mutation
- Peptide Elongation Factor Tu