Article
High frequency of altered HLA class I phenotypes in invasive colorectal carcinomas.
Tissue antigens - 1 Aug 1998
Cabrera T, Collado A, Fernandez M A, Ferron A, Sancho J, Ruiz-Cabello F, Garrido F
Abstract excerpt
We analyzed the expression of HLA class I antigens in 78 tumor tissue samples obtained from patients diagnosed as having colorectal carcinomas. A broad panel of mAbs defining HLA monomorphic, locus-specific and allele-specific determinants was used. In addition, an antibody defining HLA-C locus-specific determinant (L31) was also tested. Previous reports on these tumors indicated HLA class I losses of 30 to 40%....
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