Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-resolution analysis of HLA class I alterations in colorectal cancer.

BMC cancer - 2 Oct 2006

Dierssen Jan Willem F, de Miranda Noel F C C, Mulder Arend, van Puijenbroek Marjo, Verduyn Willem, Claas Frans H J, van de Velde Cornelis J H, Jan Fleuren Gert, Cornelisse Cees J, Corver Willem E, Morreau Hans

Abstract excerpt

BACKGROUND: Previous studies indicate that alterations in Human Leukocyte Antigen (HLA) class I expression are frequent in colorectal tumors. This would suggest serious limitations for immunotherapy-based strategies involving T-cell recognition. Distinct patterns of HLA surface expression might conceal different immune escape mechanisms employed by the tumors and are worth further study. METHOD: We applied...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Histocompatibility Antigens Class I

Share to HLA Antigens

Share to Immunohistochemistry

Share to Phenotype

Share to Ploidies

Source

Open in PubMed Open full text

Identifiers

PMID: 17014712
DOI: 10.1186/1471-2407-6-233
PMCID: PMC1599746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-resolution analysis of HLA class I alterations in colorectal cancer.PMID 17014712Read ↗

Analysis of HLA class I alterations in tumors: choosing a strategy based on known patterns of underlying molecular mechanisms.Semantic proximity Read ↗

A simple approach for detecting HLA-A*02 alleles in archival formalin-fixed paraffin-embedded tissue samples and an application example for studying cancer immunoediting.Semantic proximity Read ↗

Different mechanisms can lead to the same altered HLA class I phenotype in tumors.Semantic proximity Read ↗

HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expressionSemantic proximity Read ↗

Differential role of HLA-A and HLA-B, C expression levels as prognostic markers in colon and rectal cancerSemantic proximity Read ↗

High frequency of altered HLA class I phenotypes in invasive colorectal carcinomas.Semantic proximity Read ↗

Deregulation of HLA-I in cancer and its central importance for immunotherapySemantic proximity Read ↗

Characterization of HLA class I altered phenotypes in a panel of human melanoma cell lines.Semantic proximity Read ↗

Mechanisms of loss of HLA class I expression on colorectal tumor cellsSemantic proximity Read ↗

The biological consequences of altered MHC class I expression in tumours.Semantic proximity Read ↗

Multiple genetic alterations cause frequent and heterogeneous human histocompatibility leukocyte antigen class I loss in cervical cancer.Semantic proximity Read ↗

Loss of HLA class-I alleles, heavy chains and beta 2-microglobulin in colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.