Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development and characterization of paromomycin-resistant Leishmania donovani promastigotes.

Parasite (Paris, France) - 1 Jun 1998

Maarouf M, Adeline M T, Solignac M, Vautrin D, Robert-Gero M

Abstract excerpt

Paromomycin is an antileishmanial chemotherapeutic agent. Leishmania donovani promastigotes resistant to 800 microM of paromomycin were selected by increasing drug pressure and cloned. These promastigotes did not acquire multidrug resistance. Paromomycin resistance was stable in the absence of the drug in the culture. It remained stable also in amastigotes isolated after a passage in mice. Furthermore the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Drug Resistance, Multiple

Share to Mutation

Share to Phenotype

Share to RNA, Ribosomal

Source

Identifiers

PMID: 9754313
DOI: 10.1051/parasite/1998052167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Development and characterization of paromomycin-resistant Leishmania donovani promastigotes.PMID 9754313Read ↗

Experimental Induction of Paromomycin Resistance in Antimony-Resistant Strains of L. donovani: Outcome Dependent on In Vitro Selection ProtocolSemantic proximity Read ↗

Comparative Fitness of a Parent Leishmania donovani Clinical Isolate and Its Experimentally Derived Paromomycin-Resistant StrainSemantic proximity Read ↗

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs.Semantic proximity Read ↗

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantumSemantic proximity Read ↗

Mechanism of amphotericin B resistance in Leishmania donovani promastigotes.Semantic proximity Read ↗

Monitoring drug resistance in leishmaniasis.Semantic proximity Read ↗

Paromomycin resistance in Leishmania tropica: lack of correlation with mutation in the small subunit ribosomal RNA gene.Semantic proximity Read ↗

An axenic amastigote system for drug screeningSemantic proximity Read ↗

Selection and phenotype characterisation of sitamaquine-resistant promastigotes of Leishmania donovani.Semantic proximity Read ↗

Phenotypic characterization of Leishmania mexicana pentamidine-resistant promastigotes. Modulation of the resistance during in-vitro developmental life cycle.Semantic proximity Read ↗

Alpha-difluoromethylornithine-resistant cell lines obtained after one-step selection of Leishmania mexicana promastigote cultures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.