Article
Development and characterization of paromomycin-resistant Leishmania donovani promastigotes.
Parasite (Paris, France) - 1 Jun 1998
Maarouf M, Adeline M T, Solignac M, Vautrin D, Robert-Gero M
Abstract excerpt
Paromomycin is an antileishmanial chemotherapeutic agent. Leishmania donovani promastigotes resistant to 800 microM of paromomycin were selected by increasing drug pressure and cloned. These promastigotes did not acquire multidrug resistance. Paromomycin resistance was stable in the absence of th...
Topics
- Animals
- Anti-Bacterial Agents
- Antiprotozoal Agents
- Chromatography, High Pressure Liquid
- Drug Resistance
- Drug Resistance, Multiple
- Leishmania donovani
- Mice
- Mutation
- Paromomycin
- Phenotype
- RNA, Protozoan
- RNA, Ribosomal