Article
Paromomycin resistance in Leishmania tropica: lack of correlation with mutation in the small subunit ribosomal RNA gene.
The American journal of tropical medicine and hygiene - 1 Dec 1994
Fong D, Chan M M, Rodriguez R, Gately L J, Berman J D, Grogl M
Abstract excerpt
The aminoglycoside antibiotic paromomycin is a potentially useful anti-leishmanial chemotherapeutic agent. Resistance to this antibiotic was studied using Leishmania tropica. Promastigotes resistant to 210 micrograms/ml of paromomycin were selected by exposing them to gradual increments of this drug. Previous work in Escherichia coli, Tetrahymena, and yeast mitochondrial mutants has demonstrated mutations in the...
Topics
- Animals
- Base Sequence
- Cloning, Molecular
- DNA Primers
- DNA, Protozoan
- DNA, Ribosomal
- Drug Resistance
- Genes, Protozoan
- Leishmania tropica
- Molecular Sequence Data
- Mutation