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Article

Mechanism of amphotericin B resistance in Leishmania donovani promastigotes.

Antimicrobial agents and chemotherapy - 1 Feb 1998

Mbongo N, Loiseau P M, Billion M A, Robert-Gero M

Abstract excerpt

Amphotericin B (AmB)-resistant Leishmania donovani promastigotes were selected by increasing drug pressure, and their biological features were compared with those of the wild-type parent strain. The 50% inhibitory concentration for resistant cells was 20 times higher than that for the wild-type. Resistance was stable after more than 40 passages in drug-free medium, and resistant promastigotes were infective to...

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Identifiers

PMID: 9527785
DOI: 10.1128/AAC.42.2.352
PMCID: PMC105413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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