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Article

Selection and phenotype characterisation of sitamaquine-resistant promastigotes of Leishmania donovani.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Mar 2008

Bories Christian, Cojean Sandrine, Huteau Françoise, Loiseau Philippe M

Abstract excerpt

A Leishmania donovani promastigote line resistant to 160microM sitamaquine, named SITA-160R, was selected in vitro by continuous stepwise drug pressure. SITA-160R line was able to infect murine peritoneal macrophages in vitro in the same manner as the wild-type line (WT) but was less infective for Balb/c mice than its parent WT clone. This line was about five and three times more resistant to sitamaquine than the...

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PMID: 18249083
DOI: 10.1016/j.biopha.2007.12.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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