Article
Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator.
Molecular cell - 1 Nov 1999
Kanuka H, Sawamoto K, Inohara N, Matsuno K, Okano H, Miura M
Abstract excerpt
We identified a Drosophila Apaf-1/CED-4 homolog gene, dapaf-1. Alternative splicing results in two dapaf-1 mRNA species, which encode distinct forms of caspase activator, Dapaf-1L (Apaf-1 type) and Dapaf-1S (CED-4 type). Distinct caspases were activated by these Dapaf-1 isoforms. Loss of Dapaf-1 function resulted in defective cytochrome c-dependent caspase activities and reduced apoptosis in embryo and in larval...
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