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Intrinsic apoptosis is evolutionarily divergent among metazoans

6 Nov 2023

Abstract excerpt

Apoptosis is regulated cell death that depends on caspases. A specific initiator caspase is involved upstream of each apoptotic signaling pathway. Characterized in nematode, fly, and mammals, intrinsic apoptosis is considered to be ancestral, conserved among animals, and depends on shared initiators: caspase-9, Apaf-1 and Bcl-2. However, the biochemical role of mitochondria, the pivotal function of cytochrome c...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38525035
DOI: 10.1093/evlett/qrad057

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