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Article

Three new types of Apaf-1 in mammalian cells.

Biochemical and biophysical research communications - 11 Aug 1999

Hahn C, Hirsch B, Jahnke D, Dürkop H, Stein H

Abstract excerpt

Apaf-1, the human C. elegans Ced-4 homologue, plays a crucial role in mitochondrial mediated apoptosis. To determine whether a mutant Apaf-1 is involved in the pathogenesis of malignant lymphomas, we performed sequence analysis of its transcriptional gene product. Therefore, cDNAs coding for Apaf-1 were examined in six lymphoma derived cell lines, in three non-lymphoid tumor cell lines, as well as in peripheral...

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Identifiers

PMID: 10441496
DOI: 10.1006/bbrc.1999.1124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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