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Article

Hirudin variants production by genetic engineered microbial factory.

Biotechnology & genetic engineering reviews - 1 Oct 2018

Zhang Jianguo, Lan Nana

Abstract excerpt

Hirudin was discovered as an active anticoagulant in leech extracts almost 60 years ago. Since their initial discovery, hirudin and its variants have been produced with various anti-thrombotic, cancer cell inhibition, diabetic cataract treatment and anti-fatigue activities. Some hirudin variants have been approved for clinical use and released into the marketplace. Recent progress has seen made in relation to...

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PMID: 30095033
DOI: 10.1080/02648725.2018.1506898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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