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Article

Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death.

The Journal of biological chemistry - 9 Apr 2004

Daroui Parima, Desai Shyamal D, Li Tsai-Kun, Liu Angela A, Liu Leroy F

Abstract excerpt

Reactive oxygen species modify DNA, generating various DNA lesions including modified bases such as 8-oxoguanine (8-oxoG). These base-modified DNA lesions have been shown to trap DNA topoisomerase I (TOP1) into covalent cleavage complexes. In this study, we have investigated the role of TOP1 in hydrogen peroxide toxicity. We showed that ectopic expression of TOP1 in Saccharomyces cerevisiae conferred sensitivity...

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Source

Identifiers

PMID: 14688260
DOI: 10.1074/jbc.M311370200

Genes

TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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