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Article

Structure-function relationships in the ezrin family and the effect of tumor-associated point mutations in neurofibromatosis 2 protein.

Biochimica et biophysica acta - 8 Sept 1998

Turunen O, Sainio M, Jääskeläinen J, Carpén O, Vaheri A

Abstract excerpt

Ezrin, radixin and moesin (ERM proteins) link cell adhesion molecules to the cytoskeleton, modulate cell morphology and cell growth and are involved in Rho-mediated signal transduction. Merlin, the tumor suppressor in neurofibromatosis 2, is a diverged member of the ezrin family, but its function...

Topics

Animals
Blood Proteins
Cytoskeletal Proteins
Genes, Tumor Suppressor
Humans
Membrane Proteins
Mutation
Neurofibromatosis 2
Neurofibromin 2
Phosphoproteins
Phylogeny
Protein Structure, Secondary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Structure-Activity Relationship

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Identifiers

PMID: 9748471
DOI: 10.1016/s0167-4838(98)00103-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9748471-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Structure-function relationships in the ezrin family and the effect of tumor-associated point mutations in neurofibromatosis 2 protein.PMID 9748471Read ↗

The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene productSemantic proximity Read ↗

A glimpse of the ERM proteinsSemantic proximity Read ↗

Pathophysiological Roles of Actin-Binding Scaffold Protein, EzrinSemantic proximity Read ↗

Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A ReviewSemantic proximity Read ↗

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.Semantic proximity Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular LocalizationSemantic proximity Read ↗

Protein 4.1 tumor suppressors: getting a FERM grip on growth regulationSemantic proximity Read ↗

The Janus-faced role of ezrin in "linking" cells to either normal or metastatic phenotype.Semantic proximity Read ↗

Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrinSemantic proximity Read ↗

ERM proteins in cancer progressionSemantic proximity Read ↗

Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cellsSemantic proximity Read ↗

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