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Article

The Muscle Regulatory Factors MyoD and Myf-5 Undergo Distinct Cell Cycle–specific Expression in Muscle Cells

21 Sept 1998

Abstract excerpt

The muscle regulators MyoD and Myf-5 control cell cycle withdrawal and induction of differentiation in skeletal muscle cells. By immunofluorescence analysis, we show that MyoD and Myf-5 expression patterns become mutually exclusive when C2 cells are induced to differentiate with Myf-5 staining present in cells which fail to differentiate. Isolation of these undifferentiated cells reveals that upon serum...

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PMID: 9744876
DOI: 10.1083/jcb.142.6.1447

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Related research

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The Muscle Regulatory Factors MyoD and Myf-5 Undergo Distinct Cell Cycle–specific Expression in Muscle CellsPMID 9744876Read ↗

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Myf-5 and myoD genes are activated in distinct mesenchymal stem cells and determine different skeletal muscle cell lineages.Semantic proximity Read ↗

Autonomous differentiation in the mouse myogenic cell line, C2, involves a mutual positive control between insulin-like growth factor II and MyoD, operating as early as at the myoblast stageSemantic proximity Read ↗

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A Novel In Vitro Model for Studying Quiescence and Activation of Primary Isolated Human MyoblastsSemantic proximity Read ↗

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