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Article

Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling.

FEBS letters - 23 May 2005

Imoto Seiyu, Sugiyama Kenji, Sekine Yuichi, Matsuda Tadashi

Abstract excerpt

Sma and MAD-related protein 3 (Smad3) plays a key role in the intracellular signaling of the transforming growth factor-beta (TGF-beta) family of growth factors, which exhibits a diverse set of cellular responses, including cell proliferation and differentiation. Smad3 has the N-terminal Mad homology (MH) 1 and the C-terminal MH2 domains. MH2 domain is essential for the TGF-beta-induced transcriptional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15907489
DOI: 10.1016/j.febslet.2005.04.023

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