DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast.

doi:10.1242/jcs.108.9.3109

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Article

DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast.

Journal of cell science - 1 Sept 1995

D'Urso G, Grallert B, Nurse P

Abstract excerpt

Genetic analysis in the yeast Schizosaccharomyces pombe has shown that three genes cdc18, cut5, and cdt1, are essential for DNA synthesis and also for the checkpoint control that couples completion of DNA replication to the onset of mitosis. To test whether assembly of the replication initiation...

Topics

Binding Sites
Catalysis
DNA Polymerase II
DNA Replication
Genes, Fungal
Hydroxyurea
Mitosis
Mutation
Phenotype
S Phase
Schizosaccharomyces
Spores, Fungal
Temperature

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