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Article

DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast.

Journal of cell science - 1 Sept 1995

D'Urso G, Grallert B, Nurse P

Abstract excerpt

Genetic analysis in the yeast Schizosaccharomyces pombe has shown that three genes cdc18, cut5, and cdt1, are essential for DNA synthesis and also for the checkpoint control that couples completion of DNA replication to the onset of mitosis. To test whether assembly of the replication initiation complex is an important element in the checkpoint control pathway we have investigated if DNA polymerase alpha (pol1),...

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Identifiers

PMID: 8537450
DOI: 10.1242/jcs.108.9.3109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast.PMID 8537450Read ↗

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.Semantic proximity Read ↗

A checkpoint that monitors cytokinesis in Schizosaccharomyces pombe.Semantic proximity Read ↗

The chk1 pathway is required to prevent mitosis following cell-cycle arrest at 'start'.Semantic proximity Read ↗

The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage.Semantic proximity Read ↗

Mutational effect of fission yeast polalpha on cell cycle events.Semantic proximity Read ↗

Role of fission yeast primase catalytic subunit in the replication checkpoint.Semantic proximity Read ↗

Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+.Semantic proximity Read ↗

A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints.Semantic proximity Read ↗

Rad18 is required for DNA repair and checkpoint responses in fission yeast.Semantic proximity Read ↗

Cdc18p can block mitosis by two independent mechanisms.Semantic proximity Read ↗

The S. pombe zfs1 gene is required to prevent septation if mitotic progression is inhibited.Semantic proximity Read ↗

Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity.Semantic proximity Read ↗

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