Article
A Phg2-Adrm1 pathway participates in the nutrient-controlled developmental response in Dictyostelium.
Molecular biology of the cell - 1 Dec 2006
Cherix Nathalie, Froquet Romain, Charette Steve J, Blanc Cédric, Letourneur François, Cosson Pierre
Abstract excerpt
Dictyostelium amoebae grow as single cells but upon starvation they initiate multicellular development. Phg2 was characterized previously as a kinase controlling cellular adhesion and the organization of the actin cytoskeleton. Here we report that Phg2 also plays a role during the transition between growth and multicellular development, as evidenced by the fact that phg2 mutant cells can initiate development even...
Topics
- Animals
- Dictyostelium
- Food
- Food Deprivation
- Membrane Glycoproteins
- Mutation
- Protein Binding
- Protein Structure, Tertiary
- Protozoan Proteins