Article
GxcDD, a putative RacGEF, is involved in Dictyostelium development.
BMC cell biology - 20 Jun 2007
Mondal Subhanjan, Neelamegan Dhamodharan, Rivero Francisco, Noegel Angelika A
Abstract excerpt
BACKGROUND: Rho subfamily GTPases are implicated in a large number of actin-related processes. They shuttle from an inactive GDP-bound form to an active GTP-bound form. This reaction is catalysed by Guanine nucleotide exchange factor (GEFs). GTPase activating proteins (GAPs) help the GTPase return to the inactive GDP-bound form. The social amoeba Dictyostelium discoideum lacks a Rho or Cdc42 ortholog but has...
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