Article
Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry.
The Journal of clinical investigation - 15 Sept 1998
Chen J, Knowles H J, Hebert J L, Hackett B P
Abstract excerpt
Winged helix transcription factors play important roles in cellular differentiation and cell-specific gene expression. To define the role of the winged helix factor hepatocyte nuclear factor/forkhead homologue (HFH)-4, a targeted mutation was created in the mouse hfh-4 gene. No expression of HFH-...
Topics
- Abnormalities, Multiple
- Animals
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Body Patterning
- Choroid Plexus
- Cilia
- DNA-Binding Proteins
- Dyneins
- Female
- Forkhead Transcription Factors
- Growth
- Hepatocyte Nuclear Factor 4
- Kartagener Syndrome
- Lung
- Male
- Mice
- Mutation
- Nuclear Proteins