Article
Mutations in the dim-1 gene of Neurospora crassa reduce the level of DNA methylation.
Molecular & general genetics : MGG - 1 Jul 1998
Foss H M, Roberts C J, Selker E U
Abstract excerpt
Mutants that show reduced DNA methylation were identified in a mutant screen based on the assumptions that (i) the nucleoside analog 5-azacytidine (5-azaC) promotes the formation of potentially lethal DNA-methyltransferase adducts; (ii) reduction in DNA methyltransferase will decrease the sensitivity of cells to 5-azaC; and (iii) this potential selective advantage will be enhanced in mutants that are deficient in...
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