Mutations in the dim-1 gene of Neurospora crassa reduce the level of DNA methylation.

doi:10.1007/s004380050789

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Article

Mutations in the dim-1 gene of Neurospora crassa reduce the level of DNA methylation.

Molecular & general genetics : MGG - 1 Jul 1998

Foss H M, Roberts C J, Selker E U

Abstract excerpt

Mutants that show reduced DNA methylation were identified in a mutant screen based on the assumptions that (i) the nucleoside analog 5-azacytidine (5-azaC) promotes the formation of potentially lethal DNA-methyltransferase adducts; (ii) reduction in DNA methyltransferase will decrease the sensiti...

Topics

Azacitidine
DNA Methylation
DNA Modification Methylases
Gene Expression Regulation, Fungal
Genes, Fungal
Genetic Complementation Test
Methyl Methanesulfonate
Models, Genetic
Mutation
Neurospora crassa
Substrate Specificity

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