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Article

Selection and Characterization of Mutants Defective in DNA Methylation in Neurospora crassa.

Genetics - 1 Nov 2020

Klocko Andrew D, Summers Calvin A, Glover Marissa L, Parrish Robert, Storck William K, McNaught Kevin J, Moss Nicole D, Gotting Kirsten, Stewart Aurelian, Morrison Ariel M, Payne Laurel, Hatakeyama Shin, Selker Eric U

Abstract excerpt

DNA methylation, a prototypical epigenetic modification implicated in gene silencing, occurs in many eukaryotes and plays a significant role in the etiology of diseases such as cancer. The filamentous fungus Neurospora crassa places DNA methylation at regions of constitutive heterochromatin such as in centromeres and in other A:T-rich regions of the genome, but this modification is dispensable for normal growth...

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Identifiers

PMID: 32873602
DOI: 10.1534/genetics.120.303471
PMCID: PMC7648584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Selection and Characterization of Mutants Defective in DNA Methylation in Neurospora crassa.PMID 32873602Read ↗

Identification of DIM-7, a protein required to target the DIM-5 H3 methyltransferase to chromatin.Semantic proximity Read ↗

The DMM complex prevents spreading of DNA methylation from transposons to nearby genes in Neurospora crassa.Semantic proximity Read ↗

Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation.Semantic proximity Read ↗

H2B- and H3-specific histone deacetylases are required for DNA methylation in Neurospora crassa.Semantic proximity Read ↗

Methylation of histone H3 lysine 36 is required for normal development in Neurospora crassa.Semantic proximity Read ↗

High-density detection of restriction-site-associated DNA markers for rapid mapping of mutated loci in Neurospora.Semantic proximity Read ↗

The LSH/DDM1 Homolog MUS-30 Is Required for Genome Stability, but Not for DNA Methylation in Neurospora crassa.Semantic proximity Read ↗

Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa.Semantic proximity Read ↗

dim-2 encodes a DNA methyltransferase responsible for all known cytosine methylation in Neurospora.Semantic proximity Read ↗

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Heterochromatin protein 1 forms distinct complexes to direct histone deacetylation and DNA methylation.Semantic proximity Read ↗

A targeted-replacement system for identification of signals for de novo methylation in Neurospora crassa.Semantic proximity Read ↗

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