Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation.

doi:10.1126/science.7505062

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Article

Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation.

Science (New York, N.Y.) - 10 Dec 1993

Foss H M, Roberts C J, Claeys K M, Selker E U

Abstract excerpt

The function and regulation of DNA methylation in eukaryotes remain unclear. Genes affecting methylation were identified in the fungus Neurospora crassa. A mutation in one gene, dim-2, resulted in the loss of all detectable DNA methylation. Abnormal segregation of the methylation defects in cross...

Topics

5-Methylcytosine
Aneuploidy
Azacitidine
Blotting, Southern
Chromosomes, Fungal
Crosses, Genetic
Cytosine
DNA, Fungal
Genes, Fungal
Genetic Complementation Test
Methionine
Methylation
Mutation
Neurospora crassa
Phenotype
S-Adenosylmethionine

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