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Article

Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation.

Science (New York, N.Y.) - 10 Dec 1993

Foss H M, Roberts C J, Claeys K M, Selker E U

Abstract excerpt

The function and regulation of DNA methylation in eukaryotes remain unclear. Genes affecting methylation were identified in the fungus Neurospora crassa. A mutation in one gene, dim-2, resulted in the loss of all detectable DNA methylation. Abnormal segregation of the methylation defects in crosses led to the discovery that the methylation mutants frequently generate strains with extra chromosomes or chromosomal...

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Identifiers

PMID: 7505062
DOI: 10.1126/science.7505062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation.PMID 7505062Read ↗

Selection and Characterization of Mutants Defective in DNA Methylation in Neurospora crassa.Semantic proximity Read ↗

Mutations in the dim-1 gene of Neurospora crassa reduce the level of DNA methylation.Semantic proximity Read ↗

dim-2 encodes a DNA methyltransferase responsible for all known cytosine methylation in Neurospora.Semantic proximity Read ↗

The DMM complex prevents spreading of DNA methylation from transposons to nearby genes in Neurospora crassa.Semantic proximity Read ↗

Methylation of histone H3 lysine 36 is required for normal development in Neurospora crassa.Semantic proximity Read ↗

The LSH/DDM1 Homolog MUS-30 Is Required for Genome Stability, but Not for DNA Methylation in Neurospora crassa.Semantic proximity Read ↗

Identification of DIM-7, a protein required to target the DIM-5 H3 methyltransferase to chromatin.Semantic proximity Read ↗

DNA methylation in eukaryotes.Semantic proximity Read ↗

Mutations affecting the biosynthesis of S-adenosylmethionine cause reduction of DNA methylation in Neurospora crassa.Semantic proximity Read ↗

DNA methylation is independent of RNA interference in Neurospora.Semantic proximity Read ↗

Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa.Semantic proximity Read ↗

High-density detection of restriction-site-associated DNA markers for rapid mapping of mutated loci in Neurospora.Semantic proximity Read ↗

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