Article
Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast.
The EMBO journal - 15 Sept 1998
Isakoff S J, Cardozo T, Andreev J, Li Z, Ferguson K M, Abagyan R, Lemmon M A, Aronheim A, Skolnik E Y
Abstract excerpt
Phosphatidylinositol 3-kinase (PI3K) mediates a variety of cellular responses by generating PtdIns(3,4)P2 and PtdIns(3,4,5)P3. These 3-phosphoinositides then function directly as second messengers to activate downstream signaling molecules by binding pleckstrin homology (PH) domains in these sign...
Topics
- Amino Acid Sequence
- Blood Proteins
- Cell Membrane
- Consensus Sequence
- Conserved Sequence
- Fungal Proteins
- Models, Molecular
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphatidylinositol Phosphates
- Phosphoproteins
- Protein Binding
- Recombinant Fusion Proteins