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Article

Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones.

Antimicrobial agents and chemotherapy - 1 Feb 1997

Pan X S, Fisher L M

Abstract excerpt

gyrA and parC mutations have been identified inn Streptococcus pneumoniae mutants stepwise selected for resistance to sparfloxacin, an antipneumococcal fluoroquinolone. GyrA mutations (at the position equivalent to resistance hot spot Ser-83 in Escherichia coli GyrA) were found in all 17 first-step mutants examined and preceded DNA topoisomerase IV parC mutations (at Ser-79 or Glu-83), which appeared only in...

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Source

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Identifiers

PMID: 9021211
DOI: 10.1128/AAC.41.2.471
PMCID: PMC163733

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Source receipt: pubmed, retrieved 7 Sept 2026.

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