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Article

Adenomatous polyposis coli gene mutation alters proliferation through its beta-catenin-regulatory function in aggressive fibromatosis (desmoid tumor).

The American journal of pathology - 1 Sept 1998

Li C, Bapat B, Alman B A

Abstract excerpt

Aggressive fibromatosis is a monoclonal proliferation of spindle (fibroblast-like) cells. A subset of lesions contain somatic truncating adenomatous polyposis coli (APC) gene mutations, and all of the lesions contain an elevated beta-catenin protein level. A major function of APC is to regulate beta-catenin protein level. Beta-catenin has a dual function in the cell: it is a member of the adherens junction, and...

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Identifiers

PMID: 9736021
DOI: 10.1016/s0002-9440(10)65614-3
PMCID: PMC1853030

Genes

APC

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