Article
Adenomatous polyposis coli gene mutation alters proliferation through its beta-catenin-regulatory function in aggressive fibromatosis (desmoid tumor).
The American journal of pathology - 1 Sept 1998
Li C, Bapat B, Alman B A
Abstract excerpt
Aggressive fibromatosis is a monoclonal proliferation of spindle (fibroblast-like) cells. A subset of lesions contain somatic truncating adenomatous polyposis coli (APC) gene mutations, and all of the lesions contain an elevated beta-catenin protein level. A major function of APC is to regulate b...
Topics
- Apoptosis
- Blotting, Western
- Cadherins
- Cell Division
- Cytoskeletal Proteins
- Desmoid Tumors
- Genes, APC
- Humans
- Immunoenzyme Techniques
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Mutation
- Trans-Activators
- Transfection
- Tumor Cells, Cultured
- beta Catenin