Article
Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor).
Oncogene - 11 Nov 1999
Tejpar S, Nollet F, Li C, Wunder J S, Michils G, dal Cin P, Van Cutsem E, Bapat B, van Roy F, Cassiman J J, Alman B A
Abstract excerpt
Aggressive fibromatosis (also called desmoid tumor) occurs as a sporadic lesion or as part of Familial Adenomatous Polyposis, which is caused by germ line mutations in the Adenomatous polyposis Coli (APC) gene. APC is involved in the regulation of the cellular level of beta-catenin, which is a mediator in Wnt signaling. Mutational analysis of the beta-catenin and APC genes was performed in 42 sporadic aggressive...
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