Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paclitaxel (Taxol®): A success story with valuable lessons for natural product drug discovery and development

1 Sept 1998

Abstract excerpt

The discovery and development of paclitaxel, which covered a time span of some 30 years, has provided some important lessons for those involved in natural product drug discovery and development. These include the adoption of novel screens as they become available, the elucidation of mechanisms of action, and addressing the supply issue at an early stage of development. These issues, as applied to paclitaxel, are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 protein interactions
Share to Cancer Treatment and Pharmacology
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9735872
DOI: 10.1002/(sici)1098-1128(199809)18:5<315::aid-med3>3.0.co;2-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paclitaxel (Taxol®): A success story with valuable lessons for natural product drug discovery and developmentPMID 9735872Read ↗

Microtubule-Stabilizing Natural Products as Promising Cancer TherapeuticsSemantic proximity Read ↗

Advancements in the Understanding of Paclitaxel Metabolism in Tissue CultureSemantic proximity Read ↗

From Taxus to paclitaxel: Opportunities and challenges for urban agriculture to promote human healthSemantic proximity Read ↗

A Tale of Two Tumor Targets: Topoisomerase I and Tubulin. The Wall and Wani Contribution to Cancer ChemotherapySemantic proximity Read ↗

Recent Advances in Metabolic Engineering, Protein Engineering, and Transcriptome-Guided Insights Toward Synthetic Production of TaxolSemantic proximity Read ↗

A novel step towards the heterologous biosynthesis of paclitaxel: Characterization of T1βOH taxane hydroxylaseSemantic proximity Read ↗

Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune diseaseSemantic proximity Read ↗

Regulatory microRNAs and phasiRNAs of paclitaxel biosynthesis in Taxus chinensisSemantic proximity Read ↗

Molecular effects of paclitaxel: Myths and reality (a critical review)Semantic proximity Read ↗

Production of paclitaxel by Fusarium solani isolated from Taxus celebicaSemantic proximity Read ↗

Contribution of taxane biosynthetic pathway gene expression to observed variability in paclitaxel accumulation in <i>Taxus</i> suspension culturesSemantic proximity Read ↗

Design, Synthesis, and Biological Evaluation of New-Generation TaxoidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.