Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Design, Synthesis, and Biological Evaluation of New-Generation Taxoids

9 May 2008

Abstract excerpt

Novel second-generation taxoids with systematic modifications at the C2, C10, and C3'N positions were synthesized and their structure-activity relationships studied. A number of these taxoids exhibited exceptionally high potency against multidrug-resistant cell lines, and several taxoids exhibited virtually no difference in potency against the drug-sensitive and drug-resistant cell lines. These exceptionally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Treatment and Pharmacology
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18465846
DOI: 10.1021/jm800086e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Design, Synthesis, and Biological Evaluation of New-Generation TaxoidsPMID 18465846Read ↗

Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune diseaseSemantic proximity Read ↗

Efficacy and safety of the combination of docetaxel (Taxotere) with targeted therapies in the treatment of solid malignancies.Semantic proximity Read ↗

A Tale of Two Tumor Targets: Topoisomerase I and Tubulin. The Wall and Wani Contribution to Cancer ChemotherapySemantic proximity Read ↗

DHW-221, a Dual PI3K/mTOR Inhibitor, Overcomes Multidrug Resistance by Targeting P-Glycoprotein (P-gp/ABCB1) and Akt-Mediated FOXO3a Nuclear Translocation in Non-small Cell Lung CancerSemantic proximity Read ↗

Tubulin-Interactive Natural Products as Anticancer AgentsSemantic proximity Read ↗

Paclitaxel (Taxol®): A success story with valuable lessons for natural product drug discovery and developmentSemantic proximity Read ↗

Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes.Semantic proximity Read ↗

Epothilone B and its Analogs - A New Family of Anticancer AgentsSemantic proximity Read ↗

The Taccalonolides: Microtubule Stabilizers That Circumvent Clinically Relevant Taxane Resistance MechanismsSemantic proximity Read ↗

Regulatory microRNAs and phasiRNAs of paclitaxel biosynthesis in Taxus chinensisSemantic proximity Read ↗

The clinical development of new mitotic inhibitors that stabilize the microtubuleSemantic proximity Read ↗

From Taxus to paclitaxel: Opportunities and challenges for urban agriculture to promote human healthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.