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Article

Molecular effects of paclitaxel: Myths and reality (a critical review)

8 Oct 1999

Abstract excerpt

Recent studies on paclitaxel (Taxol), a microtubule-stabilizing agent and effective anti-cancer drug, have identified numerous cellular and molecular effects, such as induction of cytokines and tumor-suppressor genes, indirect cytotoxicity due to secretion of tumor necrosis factor, vast activation of signal-transduction pathways and selective activity against cells lacking functional p53. Some of these results,...

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PMID: 10471519
DOI: 10.1002/(sici)1097-0215(19991008)83:2<151::aid-ijc1>3.0.co;2-5

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