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Article

Atm Inactivation Results in Aberrant Telomere Clustering during Meiotic Prophase

1 Jul 1999

Abstract excerpt

A-T (ataxia telangiectasia) individuals frequently display gonadal atrophy, and Atm-/- mice show spermatogenic failure due to arrest at prophase of meiosis I. Chromosomal movements take place during meiotic prophase, with telomeres congregating on the nuclear envelope to transiently form a cluster during the leptotene/zygotene transition (bouquet arrangement). Since the ATM protein has been implicated in telomere...

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Identifiers

PMID: 10373558
DOI: 10.1128/mcb.19.7.5096

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