Article
Transforming and oncogenic potential of activated c-Ha-ras in three immortalized human breast epithelial cell lines.
Anticancer research - 1 Jan 2000
Wang B, Soule H D, Miller F R
Abstract excerpt
The ability of activated c-Ha-ras (codon 12 valine) to transform human breast epithelial cells varied for three different immortalized normal human breast epithelial cell lines established from two different women. Although activated c-Ha-ras may transform and induce a preneoplastic phenotype in MCF10A cells, activated c-Ha-ras was not sufficient to transform MCF10-2A cells. Only two of three MCF10-2A clones...
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