Article
Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2.
Oncogene - 1 Dec 1994
Janes P W, Daly R J, deFazio A, Sutherland R L
Abstract excerpt
The c-erbB-2 proto-oncogene encodes a receptor tyrosine kinase (RTK) closely related to the epidermal growth factor receptor (EGFR). Overexpression of erbB-2 occurs in approximately 20% of human breast tumours, where increased expression correlates with poor patient prognosis. The EGFR is coupled...
Topics
- Adaptor Proteins, Signal Transducing
- Breast Neoplasms
- GRB2 Adaptor Protein
- Gene Expression Regulation, Neoplastic
- Genes, erbB-2
- Guanine Nucleotide Exchange Factors
- Humans
- Mitogen-Activated Protein Kinase 1
- Phenotype
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- Proteins
- Proto-Oncogene Mas
- Signal Transduction
- Tumor Cells, Cultured
- ras Guanine Nucleotide Exchange Factors