Article
Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV.
PloS one - 20 Jul 2010
Sugimoto Chie, Watanabe Satoru, Naruse Taeko, Kajiwara Eiji, Shiino Teiichiro, Umano Natsuko, Ueda Kayoko, Sato Hirotaka, Ohgimoto Shinji, Hirsch Vanessa, Villinger Francois, Ansari Aftab A, Kimura Akinori, Miyazawa Masaaki, Suzuki Yasuo, Yamamoto Naoki, Nagai Yoshiyuki, Mori Kazuyasu
Abstract excerpt
HIV vaccine development has been hampered by issues such as undefined correlates of protection and extensive diversity of HIV. We addressed these issues using a previously established SIV-macaque model in which SIV mutants with deletions of multiple gp120 N-glycans function as potent live attenuated vaccines to induce near-sterile immunity against the parental pathogenic SIVmac239. In this study, we investigated...
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