Article
Envelope vaccination shapes viral envelope evolution following simian immunodeficiency virus infection in rhesus monkeys.
Journal of virology - 1 Jan 2010
Basavapathruni Aravind, Yeh Wendy W, Coffey Rory T, Whitney James B, Hraber Peter T, Giri Ayush, Korber Bette T, Rao Srinivas S, Nabel Gary J, Mascola John R, Seaman Michael S, Letvin Norman L
Abstract excerpt
The evolution of envelope mutations by replicating primate immunodeficiency viruses allows these viruses to escape from the immune pressure mediated by neutralizing antibodies. Vaccine-induced anti-envelope antibody responses may accelerate and/or alter the specificity of the antibodies, thus sha...
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