Article
Protection of Macaca nemestrina from disease following pathogenic simian immunodeficiency virus (SIV) challenge: utilization of SIV nucleocapsid mutant DNA vaccines with and without an SIV protein boost.
Journal of virology - 1 Dec 2000
Gorelick R J, Benveniste R E, Lifson J D, Yovandich J L, Morton W R, Kuller L, Flynn B M, Fisher B A, Rossio J L, Piatak M, Bess J W, Henderson L E, Arthur L O
Abstract excerpt
Molecular clones were constructed that express nucleocapsid (NC) deletion mutant simian immunodeficiency viruses (SIVs) that are replication defective but capable of completing virtually all of the steps of a single viral infection cycle. These steps include production of particles that are viral RNA deficient yet contain a full complement of processed viral proteins. The mutant particles are ultrastructurally...
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