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Article

Influence of gene interaction on complex trait variation with multilocus models.

Genetics - 1 Sept 2014

Mäki-Tanila Asko, Hill William G

Abstract excerpt

Although research effort is being expended into determining the importance of epistasis and epistatic variance for complex traits, there is considerable controversy about their importance. Here we undertake an analysis for quantitative traits utilizing a range of multilocus quantitative genetic models and gene frequency distributions, focusing on the potential magnitude of the epistatic variance. All the...

Topics

Animals
Epistasis, Genetic
Genetic Variation
Humans
Models, Genetic
Quantitative Trait Loci
Quantitative Trait, Heritable
Selection, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24990992
DOI: 10.1534/genetics.114.165282
PMCID: PMC4174947

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