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Article

Novel mutations in the cytochrome P450 2C19 gene: a pitfall of the PCR-RFLP method for identifying a common mutation.

Journal of human genetics - 1 Jan 2006

Ohkubo Yumiko, Ueta Akihito, Ando Naoki, Ito Tetsuya, Yamaguchi Sachiko, Mizuno Kantaro, Sumi Satoshi, Maeda Tohru, Yamazaki Daiju, Kurono Yukihisa, Fujimoto Shinji, Togari Hajime

Abstract excerpt

CYP2C19 is a clinically important enzyme involved in the metabolism of therapeutic drugs such as (S)-mephenytoin, omeprazole, proguanil, and diazepam. Individuals can be characterized as either extensive metabolizers (EM) or poor metabolizers (PM) on the basis of CYP2C19 enzyme activity. The PM phenotype occurs in 2-5% of Caucasian populations, but at higher frequencies (18-23%) in Asians. CYP2C19*2 and...

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PMID: 16307177
DOI: 10.1007/s10038-005-0332-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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