Article
The B-type cyclin Clb4 prevents meiosis I sister centromere separation in budding yeast.
G3 (Bethesda, Md.) - 3 Sept 2025
Lumbroso Gal, Cairo Gisela, Lacefield Soni, Murray Andrew W
Abstract excerpt
In meiosis, one round of DNA replication followed by two rounds of chromosome segregation halves the ploidy of the original cell. Accurate chromosome segregation in meiosis I depends on recombination between homologous chromosomes. Sister centromeres attach to the same spindle pole in this division and only segregate in meiosis II. We used budding yeast to select for mutations that produced viable spores in the...
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