Retinoic acid treatment induces apoptosis or expression of a more differentiated phenotype on different fractions of cultured fetal rat hepatocytes.

doi:10.1002/hep.510280319

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Article

Retinoic acid treatment induces apoptosis or expression of a more differentiated phenotype on different fractions of cultured fetal rat hepatocytes.

Hepatology (Baltimore, Md.) - 1 Sept 1998

Falasca L, Favale A, Gualandi G, Maietta G, Conti Devirgiliis L

Abstract excerpt

The present study reports the effects of retinoic acid (RA) on cultured fetal rat hepatocytes. We show that RA treatment induces both differentiation and apoptosis. Hepatocytes cultured for 48 hours in the presence of 5 microl/L RA form junctional complexes in the areas of contact between neighbo...

Topics

Animals
Apoptosis
Cell Differentiation
Cells, Cultured
Female
Flow Cytometry
Liver
Phenotype
Rats
Rats, Wistar
Tretinoin
Tumor Suppressor Protein p53

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