Article
Growth inhibition and induction of specific hepatic phenotype expression by retinoic acid in HEPG2 cells.
Anticancer research - 1 Jan 2000
Falasca L, Marcellini P, Ara C, Rufo A, Devirgiliis L C
Abstract excerpt
Retinoic acid, the active metabolite of vitamin A, plays a role in the growth and differentiation of a variety of normal and malignant cells. In response to 5 microM retinoic acid the human hepatoma-derived cell line HepG2 underwent significant growth inhibition (not associated with cell death), which reached a level of 80% in comparison with controls, after 12 days of continuous treatment. Retinoic acid also...
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