Article
Possible involvement of Bcl-2 pathway in retinoid X receptor alpha-induced apoptosis of HL-60 cells.
Biochemical and biophysical research communications - 13 Jan 1997
Agarwal N, Mehta K
Abstract excerpt
Retinoids induce granulocytic differentiation and subsequent apoptosis in human myeloid (HL-60) leukemia cells. Differentiation is induced due to activation of retinoic acid receptors (RARs) whereas, activation of retinoid X receptors (RXRs) seems to be essential for driving these cells into apop...
Topics
- Alitretinoin
- Apoptosis
- HL-60 Cells
- Humans
- Mutation
- Oncogenes
- Polymerase Chain Reaction
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- Receptors, Retinoic Acid
- Recombinant Proteins
- Retinoic Acid Receptor alpha
- Retinoid X Receptors
- Retroviridae
- Transcription Factors
- Transcription, Genetic
- Transfection
- Tretinoin