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Article

Possible involvement of Bcl-2 pathway in retinoid X receptor alpha-induced apoptosis of HL-60 cells.

Biochemical and biophysical research communications - 13 Jan 1997

Agarwal N, Mehta K

Abstract excerpt

Retinoids induce granulocytic differentiation and subsequent apoptosis in human myeloid (HL-60) leukemia cells. Differentiation is induced due to activation of retinoic acid receptors (RARs) whereas, activation of retinoid X receptors (RXRs) seems to be essential for driving these cells into apoptosis. In order to understand the mechanism of RXR induced apoptosis, we used a variant HL-60 cell line (HL-60R) with a...

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Identifiers

PMID: 9016759
DOI: 10.1006/bbrc.1996.5937

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