Article
Maturation of peroxisomes in differentiating human hepatoblastoma cells (HepG2): possible involvement of the peroxisome proliferator-activated receptor alpha (PPAR alpha).
Differentiation; research in biological diversity - 1 Nov 1998
Stier H, Fahimi H D, Van Veldhoven P P, Mannaerts G P, Völkl A, Baumgart E
Abstract excerpt
We have studied the alterations of peroxisomes in the human hepatoblastoma cell line HepG2, induced to differentiate by long-term cultivation (20 days without passaging) using morphological and biochemical techniques as well as mRNA analysis. Ultrastructural studies revealed alterations in shape...
Topics
- Albumins
- Carcinoma, Hepatocellular
- Cell Differentiation
- Enzyme Induction
- Humans
- Liver Neoplasms
- Microbodies
- Microscopy, Electron
- Oxidoreductases
- Phenotype
- RNA, Messenger
- Receptors, Cytoplasmic and Nuclear
- Transcription Factors
- Tumor Cells, Cultured