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Article

Parental genotype reconstruction: applications of haplotype relative risk to incomplete parental data.

Genetic epidemiology - 1 Jan 1998

Martin R B, Alda M, MacLean C J

Abstract excerpt

Intended to resolve the problem of constructing a matched population-based control sample, haplotype relative risk techniques frequently suffer from loss of power for late-onset diseases due to unavailability of parental genotypes that are required to form parent-offspring pairs. However, much of this missing information can be reconstructed using the genotypes of the affected individual's siblings. For some...

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Identifiers

PMID: 9728890
DOI: 10.1002/(SICI)1098-2272(1998)15:5<471::AID-GEPI3>3.0.CO;2-3

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