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Article

Incorporating family disease history and controlling case-control imbalance for population-based genetic association studies.

Bioinformatics (Oxford, England) - 15 Sept 2022

Zhuang Yongwen, Wolford Brooke N, Nam Kisung, Bi Wenjian, Zhou Wei, Willer Cristen J, Mukherjee Bhramar, Lee Seunggeun

Abstract excerpt

MOTIVATION: In the genome-wide association analysis of population-based biobanks, most diseases have low prevalence, which results in low detection power. One approach to tackle the problem is using family disease history, yet existing methods are unable to address type I error inflation induced by increased correlation of phenotypes among closely related samples, as well as unbalanced phenotypic distribution....

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PMID: 35876838
DOI: 10.1093/bioinformatics/btac459
PMCID: PMC9477535

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