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Article

Rare variant association analysis in case-parents studies by allowing for missing parental genotypes.

BMC genetics - 15 Jan 2018

Li Yumei, Xiang Yang, Xu Chao, Shen Hui, Deng Hongwen

Abstract excerpt

BACKGROUND: The development of next-generation sequencing technologies has facilitated the identification of rare variants. Family-based design is commonly used to effectively control for population admixture and substructure, which is more prominent for rare variants. Case-parents studies, as typical strategies in family-based design, are widely used in rare variant-disease association analysis. Current methods...

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Identifiers

PMID: 29334894
DOI: 10.1186/s12863-018-0597-8
PMCID: PMC5769338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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